mTBI and Parkinson’s Disease

By on December 2nd, 2021

Posted in Brain Injury

 It has been known for some time there is an increased risk of neurologic decline following mild traumatic brain injury (mTBI). A new study published in PLOS ONE adds further proof. In a recent study, epidemiologists reported a 56% increased risk of veterans with mild traumatic brain injury developing Parkinson’s disease within 12 years post-injury. According to the researchers, “the goal of the study was to obtain evidence for premature cognitive decline in young veterans with a positive mTBI by comparing their cognitive scores against veterans without mTBI, healthy non-veteran controls and older early-stage, non-demented subjects with Parkinson’s disease.”

Inclusion/Exclusion criteria included “eligible volunteers of both men and women veterans, veterans with positive mTBI, non-veteran healthy controls (25-45/years old), and early-stage, non-demented Parkinson’s disease subjects (60-90/yrs old) with at least 12 years of education and scoring greater than or equal to 90 points on the American National Adult Reading Test (AMNART).” In addition to the non-veteran healthy controls, the researchers also recruited a military control group for the veterans with positive TBI. Non-English speaking, pregnant and any unremitted/debilitating endocrine, autoimmune, rheumatological, cardiovascular, psychiatric or neurological diseases/disorders other than mTBI or early-stage Parkinson’s disease, dementia had any physical or sensory limitations preventing completion of study procedures, alcohol, elicit or illegal substance use, or tobacco use were excluded.

The researchers also sought to exclude more severe brain injury than a concussion. As a result, the mTBI group consisted of non-penetrating mTBI, loss of consciousness of fewer than 30 minutes, any loss of memory less than 24 hours from events immediately before or after the accident, altered mental state feeling dizzy, disoriented, or confused after the accident, less than 24 hours or scores on the Glasgow Coma Scale of 13-15.

The study’s outcome found a 56% increase in the risk of veterans with a positive mild traumatic brain injury developing Parkinson’s disease within 12-years post-injury.

The citation to the study is Nejtek VA, James RN, Salvatore MF, Alphonso HM, Boehm GW (2021) Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson’s disease. PLoS ONE 16(11): e0258851. You can read the full article here.

Multiple locations to better serve your needs—

Princeton, NJ

993 Lenox Dr, Building 2
Lawrenceville, NJ 08648
Phone: 609.896.9060
Secondary phone: 800.535.3425
Fax: 609.896.0629
county best pa pennsylvania reviews south jersey berks northhampton montgomery bucks lehigh valley gloucester burlington mercer

Marlton, NJ

40 Lake Center, 401 NJ-73, Suite 130
Marlton, NJ 08053
Phone: 856.874.4443
Secondary phone: 888.241.7424
Fax: 856.874.0133
county best pa pennsylvania reviews south jersey berks northhampton montgomery bucks lehigh valley gloucester burlington mercer

Yardley, PA

777 Township Line Road, Suite 120
Yardley, PA 19067
Phone: 267.907.9600
Fax: 267.907.9659
county best pa pennsylvania reviews south jersey berks northhampton montgomery bucks lehigh valley gloucester burlington mercer

New York, NY

5 Pennsylvania Plaza 23rd Floor
New York, NY 10001
Phone: 800.535.3425
county best pa pennsylvania reviews south jersey berks northhampton montgomery bucks lehigh valley gloucester burlington mercer

Philadelphia, PA

The Bellevue 200 S Broad St #600
Philadelphia, PA 19102
Phone: 267.907.9600
Secondary phone: 800.535.3425
Fax: 215.564.6245
county best pa pennsylvania reviews south jersey berks northhampton montgomery bucks lehigh valley gloucester burlington mercer

Bridgeton, NJ

78 W Broad St
Bridgeton, NJ 08302
Phone: 856.874.4443
county best pa pennsylvania reviews south jersey berks northhampton montgomery bucks lehigh valley gloucester burlington mercer